The Buffalo Bills and Los Angeles Rams are scheduled to meet in the NFL at SoFi Stadium on Thursday, beginning at 8:20 p.m. ET.
The Bills are listed as betting favorites against the Rams on 9/8/22, with the Over/Under for total points scored set at 52.
This Bills-Rams betting preview, which contains game predictions and odds, is presented by DraftKings Sportsbook and powered by Dimers.com.
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Buffalo Bills vs. Los Angeles Rams
When and where
- Date: Thursday, September 8, 2022
- Time: 8:20 p.m. ET
- Venue: SoFi Stadium
Odds and lines
- Point spread: Rams +2 (-107), Bills -2 (-107)
- Moneyline: Rams +115, Bills -126
- Total: Over/Under 52 (-105/-110)
Odds and lines in this article are best available at time of publishing and subject to change.
Bills vs. Rams predictions
Dimers has simulated Thursday's Bills-Rams NFL game 10,000 times using trusted data and analytics to predict the most likely outcomes.
According to Dimers' predictive analytics model, the Bills have a 59% chance of beating the Rams at SoFi Stadium.
Dimers also predicts that the Bills (-2) have a 56% chance of covering the spread.
The Over/Under total of 52 points has a 54% chance of going Under.
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Predictions and probabilities are correct at time of publishing and subject to change.
Best bet for Bills vs. Rams
Our free data-driven pick for Bills vs. Rams on Thursday is Bills -2 (-107).
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All betting tips in this article are based on world-class simulations and hundreds of different inputs to help you make smarter investments.
Bills vs. Rams score prediction
Dimers' predicted final score for Buffalo vs. LA Rams at SoFi Stadium has the Bills winning 27-24.
This prediction is based on both teams' average score after 10,000 game simulations.
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The NFL Week 1 matchup between the Bills and Rams on Thursday is scheduled to begin at 8:20 p.m. ET.
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